Tle3 in cancer
WebJul 7, 2024 · Given that stabilized β-catenin promotes the E3 ligase activity of UBR5 toward TLE3, we asked whether we could detect UBR5-dependent Ub-TLE3 in the colorectal cancer cell line HCT116, whose Wnt pathway activity is elevated due to a Δ45 mutation in one of its β-catenin alleles (Morin et al., 1997). We thus used the CRISPR/Cas9 system to ... WebFeb 28, 2024 · TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas. [ …
Tle3 in cancer
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WebThis section shows a general overview of the selected mutation. It describes the source of the mutation i.e gene name/sample name/tissue name with unique ID, and also shows the mutation syntax at the amino acid and nucleotide sequence level. WebHere, we show that in breast cancer MCF-7 cells, TLE3, a co-repressor of the Groucho/Grg/TLE family, interacts with FoxA1 and is detected at regulatory elements of ERα target genes in absence of estrogen. As a result, the chromatin is maintained in a basal state of acetylation, thus preventing ligand-independent activation of transcription.
WebTLE3 also regulates metabolism and cell fate in the bone [28,29,30], pancreas [31,32,33], muscle , embryonic stem cell [35,36], and cancer [17,27,37,38,39]. It is interesting to note … WebNew selective, efficacious chemotherapy agents are in demand as traditional drugs display side effects and face growing resistance upon continued administration. To this end, bioactive molecules such as peptides are attracting interest. RT2 is a cationic peptide that was used as an antimicrobial but is being repurposed for targeting cancer. In this work, …
WebSep 27, 2016 · Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds of … WebApr 4, 2024 · Here we report that the transcriptional corepressor TLE3 is a guardian of luminal cell fate in breast cancer and operates independently of the estrogen receptor. In …
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WebIn conclusion, the present study demonstrated that miR-3677 promoted BC cell proliferation, migration and invasion by inhibiting TLE3 expression, which provided a novel mechanism and a promising therapeutic target for patients with BC. Keywords: breast cancer; cell metastasis; cell proliferation; microRNA-3677; transducin-like enhancer of Split3. prothioconazole analysis in waterWebDec 23, 2024 · Numerous studies have indicated an important function of microRNAs (miRs) in breast cancer (BC) progression, oncogenesis and metastasis. However, the function of miR‑3677, which has been revealed to be upregulated in BC [The Cancer Genome Atlas (TCGA) data], has not been investigated to date. In the present study, miR‑3677 was … prothiofos labelWebApr 13, 2024 · In this study of breast cancer patients receiving adjuvant chemotherapy at two independent institutions, TLE3 staining was associated with improved disease-free … resmed western australiaWebSep 27, 2016 · As for CRC cancer, we observed that TLE3 could cause the G1-S phase transition arrest in a certain extent and repress the growth and proliferation of CRC. Both p21 and p27 have been identified as mediators of tumor suppression through G1 or G2 arrest, involving binding to CyclinA/cyclin-dependent kinase (CDK) 2, CyclinE/CDK2, and … resmed water chamber for socleanWebTopoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer prothioconazole bayerWebhuman lung tissue were subjected to SDS PAGE followed by western blot with 11372-1-AP (TLE3 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. IP Result of anti-TLE3 (IP:11372-1-AP, 4ug; Detection:11372-1-AP 1:300) with HeLa cells lysate 1600ug. Immunohistochemical analysis of paraffin-embedded human breast cancer slide ... resmed what is humidifier warmingWebExpression of TLE3 (ESG, ESG3, GRG3, HsT18976, KIAA1547) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. resmed west columbia sc