WebChronic kidney disease can progress to end-stage kidney failure, which is fatal without artificial filtering (dialysis) or a kidney transplant. How kidneys work. Show transcript for video How kidneys work. One of the important jobs of the kidneys is to clean the blood. As blood moves through the body, it picks up extra fluid, chemicals and waste. WebPitting edema occurs when excess fluid builds up in the body, causing swelling; when pressure is applied to the swollen area, a “pit”, or indentation, will remain. Although it can affect any part of the body, pitting edema usually occurs in legs, feet, and ankles. Most cases of pitting edema are dependent or peripheral.
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